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There are several matches for 'secretion/activator protein'.
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1259 matches
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organism
protein
1)
Homo sapiens
LAG3 -
Secreted
lymphocyte
activation
gene 3
protein
; Lymphocyte
activation
gene 3
protein
: Inhibitory receptor on antigen
activated
T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell
activation
(By similarity). May inhibit antigen-specific T-cell
activation
in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/P [...]
[a.k.a. A8K7T9, ENSG00000089692, BAF84793.1]
2)
Homo sapiens
WNT10B -
Protein
Wnt-10b; Member of the Wnt ligand gene family that encodes for
secreted
proteins
, which
activate
the Wnt signaling cascade. Specifically
activates
canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.
[a.k.a. WNT-12, ENSP00000404896, R-HSA-162582]
3)
Homo sapiens
PKDCC - Extracellular tyrosine-
protein
kinase PKDCC;
Secreted
tyrosine-
protein
kinase that mediates phosphorylation of extracellular
proteins
and endogenous
proteins
in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29. Probably plays a role in platelets: rapidly and quantitatively
secreted
from platelets in response to stimulation of platelet degranulation. May also have serine/threonine
protein
kinase
activity
. Required for longitudinal bone growth through regulation of chondrocyte differentiation [...]
[a.k.a. NP_612379.2, Vlk, uc002rsg.4]
4)
Homo sapiens
SERPINA5 - Plasma serine protease inhibitor; Heparin-dependent serine protease inhibitor acting in body fluids and
secretions
. Inactivates serine proteases by binding irreversibly to their serine
activation
site. Involved in the regulation of intravascular and extravascular proteolytic
activities
. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant
activated
protein
C factor as well as the generation of
activated
protein
C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coa [...]
[a.k.a. uc059eta.1, ENST00000557598, PAI-3]
5)
Homo sapiens
RARRES2 - Retinoic acid receptor responder
protein
2; Adipocyte-
secreted
protein
(adipokine) that regulates adipogenesis, metabolism and inflammation through
activation
of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G
protein
-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an i [...]
[a.k.a. EAL24473.1, NM_002889, NP_002880]
6)
Homo sapiens
ARL4C - ADP-ribosylation factor-like
protein
4C; Small GTP-binding
protein
which cycles between an inactive GDP-bound and an
active
GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-
activating
proteins
(GAP). GTP-binding
protein
that does not act as an allosteric
activator
of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol
secretion
pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in th [...]
[a.k.a. R-HSA-162582, ADP ribosylation factor like GTPase 4C, CAE30323.1]
7)
Homo sapiens
DENND10 - DENN domain-containing
protein
10; Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and
secretion
, possibly through
activating
Rab
proteins
such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their
active
GTP- bound form; Belongs to the DENND10 family.
[a.k.a. ENST00000489988.5, XM_006717851, ENST00000489936.1]
8)
Homo sapiens
GPR75 - Probable G-
protein
coupled receptor 75; G
protein
-coupled receptor that is
activated
by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq
proteins
, it stimulates inositol trisphosphate production and calcium mobilization upon
activation
. Together with CCL5/RANTES, may play a role in neuron survival through
activation
of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin
secretion
by pancreatic islet cells through
activation
of this receptor.
[a.k.a. WI31133, AF101472, AAD22770.1]
9)
Homo sapiens
NLRP3 - NACHT, LRR and PYD domains-containing
protein
3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its
activation
and CASP1-catalyzed IL1B and IL18 maturation and
secretion
in the extracellular milieu.
Activation
of NLRP3 inflammasome is also required for HMGB1
secretion
. The
active
cytokin [...]
[a.k.a. NM_004895.4, ENST00000532083, XM_024452862.1]
10)
Homo sapiens
NLRP1 - NACHT, LRR and PYD domains-containing
protein
1; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its
activation
and CASP1-catalyzed IL1B and IL18 maturation and
secretion
in the extracellular milieu.
Activation
of NLRP1 inflammasome is also required for HMGB1
secretion
. The
active
cytokines and HMGB1 stimulat [...]
[a.k.a. ENSP00000460475, VAMAS1, R-HSA-844455]
11)
Homo sapiens
CADPS - Calcium-dependent
secretion
activator
1; Calcium-binding
protein
involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2- binding
protein
that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in [...]
[a.k.a. Calcium-dependent secretion activator 1, XM_017007380.2, XP_024309567.1]
12)
Homo sapiens
CADPS2 - Calcium-dependent
secretion
activator
2; Calcium-binding
protein
involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).
[a.k.a. NM_001363393.1, NP_001350326, NX_Q86UW7]
13)
Homo sapiens
MAPKBP1 - Mitogen-
activated
protein
kinase-binding
protein
1; Negative regulator of NOD2 function. It down-regulates NOD2- induced processes such as
activation
of NF-kappa-B signaling, IL8
secretion
and antibacterial response. Involved in JNK signaling pathway (By similarity).
[a.k.a. CCDS32201, MAPKBP1-205, ENST00000627631]
14)
Homo sapiens
HRH2 - Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid
secretion
. Also appears to regulate gastrointestinal motility and intestinal
secretion
. Possible role in regulating cell growth and differentiation. The
activity
of this receptor is mediated by G
proteins
which
activate
adenylyl cyclase and, through a separate G
protein
-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity); Belongs to the G-
protein
coupled receptor 1 family.
[a.k.a. R-HSA-388396, R-HSA-162582, XM_017009426.2]
15)
Homo sapiens
DEAF1 - Deformed epidermal autoregulatory factor 1 homolog; Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'.
Activates
the proenkephalin gene independently of promoter binding, probably through
protein
-
protein
interaction. When
secreted
, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. [...]
[a.k.a. ENSP00000320602, 2JW6, XM_024448326.1]
16)
Homo sapiens
CCDC134 - Coiled-coil domain-containing
protein
134; In extracellular
secreted
form, promotes proliferation and
activation
of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor
activity
of CD8(+) T cells. May inhibit ERK and JNK signaling
activity
. May suppress cell migration and invasion
activity
, via its effects on ERK and JNK signaling.
[a.k.a. NM_024821.3, NP_079097, FLJ22349]
17)
Homo sapiens
NDFIP1 - NEDD4 family-interacting
protein
1;
Activates
HECT domain-containing E3 ubiquitin-
protein
ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by
activating
ITCH and thus controlling JUNB degradation (By similarity). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded
protein
response, leading to reduction of insulin
secretion
. Restricts the production of proinflammatory cytokines in effector Th17 T-cells [...]
[a.k.a. ENST00000253814, 80762, NP_085048.1]
18)
Homo sapiens
SLURP1 -
Secreted
Ly-6/uPAR-related
protein
1; Has an antitumor
activity
. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs)
activity
. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells may be involved in regulation of intracellular Ca(2+) signaling. Seems to have an immunomodulatory functi [...]
[a.k.a. ARS(component B)-81/S, ARS, Secreted Ly-6/uPAR-related protein 1]
19)
Homo sapiens
PIM3 - Serine/threonine-protein kinase pim-3; Proto-oncogene with serine/threonine kinase
activity
that can prevent apoptosis, promote cell survival and
protein
translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti- apoptotic
protein
Bcl-X(L), the regulation of cell cycle progression,
protein
synthesis and by regulation of MYC transcriptional
activity
. Additionally to this role on tumorigenesis, can also negatively regulate insulin
secretion
by inhibiting the
activation
of MAPK1/3 (ERK1/2), thr [...]
[a.k.a. AB114795, CCDS33678.1, OTTHUMG00000150290]
20)
Homo sapiens
PPBP - Connective tissue-
activating
peptide III(1-81); LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2
secretion
, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and
secretion
of plasminogen
activator
by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and
activators
for neutrophils. TC-1 and TC-2 are antibacterial
proteins
, in vitro released from
activated
platelet alpha-granules. C [...]
[a.k.a. B2R5F3, R-HSA-388396, NAP-2-L1]
1259 matches
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